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Rock Star Review of Critical Care Literature – 2019

November 12, 2020

Written by Clay Smith

Spoon Feed
These emergency/critical care pros recount their favorite critical care articles from 2019.

Why does this matter?
Signal to noise – there is so much being published every day it can be hard to tell what’s important. These authors have selected 11 articles from 2019 that they think are the most important.

CC lit 2019 in a nutshell
Here are the top 11 articles from these rock star authors.

  1. Hernandez G, et al. Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: The ANDROMEDA-SHOCK randomized clinical trial. JAMA. 2019; 321:654–664.
    “No difference in all-cause 28-day mortality between patients who received a peripheral perfusion resuscitation strategy [vs lactate-guided]. Patients in the peripheral perfusion resuscitation strategy group received less IVFs and had less organ dysfunction.”
    JournalFeed coverage of ANDROMEDA-SHOCK and a Bayesian reanalysis
  2. Permpikul C, et al. Early use of norepinephrine in septic shock resuscitation (CENSER). A randomized trial. Am J Respir Crit Care Med. 2019; 199:1097–1105.
    “Shock control and shock resolution occurred more often in patients randomized to NE infusion compared to patients randomized to placebo. Lower incidence of pulmonary edema and arrhythmias in patients randomized to NE. No difference in 28-day mortality or hospital mortality.”
    JournalFeed coverage of CENSER
  3. Fowler AA, et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRUS-ALI randomized clinical trial. JAMA. 2019; 322:1261–1270.
    ”No difference in the modified SOFA score at 96 h or in C-reactive protein and thrombomodulin levels at 168 h between those who received vitamin C and those who received placebo.”
    JournalFeed coverage of CITRUS-ALI
  4. Casey JD, et al. Bag-mask ventilation during tracheal intubation of critically ill adults. N Engl J Med. 2019; 380:811–821.
    ”The use of BMV during the interval between RSI medication administration and laryngoscopy resulted in a higher oxygen saturation and lower incidence of severe hypoxemia compared with those who did not receive BMV.”
    JournalFeed coverage of PreVent
  5. Janz DR, et al. Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): A randomized controlled trial. Lancet Respir Med. 2019; 7:1039–1047.
    ”No difference in the composite primary outcomes for cardiovascular collapse in patients who received IVFs during RSI compared with patients who did not receive IVFs.”
    JournalFeed coverage of PrePARE
  6. ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Conservative oxygen therapy during mechanical ventilation in the ICU. N Engl J Med. 2019.
    ”No significant difference in ventilator-free days at day 28 for patients treated with a conservative oxygen therapy compared with patients treated with usual care.”
    JournalFeed coverage of ICU-ROX
  7. Kapur J, et al. Randomized trial of three anticonvulsant medications for status epilepticus. N Engl J Med. 2019; 381:2103–2113.
    ”No significant difference between levetiracetam, valproic acid, or fosphenytoin to terminate seizures and improve responsiveness at 60 min in patients with status epilepticus.”
    JournalFeed coverage of ESETT
  8. CRASH-3 Trial Collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): A randomized, placebo-controlled trial. Lancet. 2019; 394:1712.
    ”No significant difference in the primary outcome of 28-day head injury associated in-hospital mortality among patients who received TXA compared to placebo. A significant difference in the primary outcome was found in a pre-specified subgroup analysis of patients with mild to moderate TBI (GCS 9–15) in patients who received TXA compared to placebo.”
    JournalFeed coverage of CRASH-3
  9. Lemkes JS, et al. Coronary angiography after cardiac arrest without ST-segment elevation. N Engl J Med. 2019; 380:1397–1407.
    ”No significant difference in 90-day survival in patients randomized to immediate angiography compared to those randomized to delayed angiography.”
    JournalFeed coverage of COACT
  10. Lascarrou JB, et al. Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med. 2019; 381:2327–2337.
    ”Favorable neurologic survival at 90-days was higher in patients who received moderate hypothermia (33C) compared to those that were randomized to normothermia (36.5–37.5 °C)”
    JournalFeed coverage of TTM study
  11. Gunnerson KJ, et al. Association of an emergency department-based intensive care unit with survival and inpatient intensive care unit admissions. JAMA Netw Open. 2019;2:e197584.
    ”Implementation of an ED-based ICU led to a reduction in 30-day mortality and decreased ICU admissions for critically ill ED patients.”

The critical care literature 2019. Am J Emerg Med. 2020 Sep 28;S0735-6757(20)30854-8. doi: 10.1016/j.ajem.2020.09.059. Online ahead of print.

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