Prognostic Value of Blood-Based Protein Biomarkers in Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis.
Mondello S, Amrein K, Czeiter E, Citerio G et al. Prognostic Value of Blood-Based Protein Biomarkers in Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis. Journal of neurotrauma. 2025 May 28. PMID: 40432557.
Summary: This living systematic review and meta-analysis of 7481 adult TBI patients found that admission GFAP and UCH-L1 levels are strongly associated with mortality, potentially improving risk stratification but currently lacking sufficient evidence for routine clinical implementation without further rigorous analysis to demonstrate prognostic actionability.
Damage control thoracotomy trends, techniques, and outcomes: An EAST multicenter trial.
Douglas AD, Puzio T, Murphy P, Nahmias J et al. Damage control thoracotomy trends, techniques, and outcomes: An EAST multicenter trial. The journal of trauma and acute care surgery. 2025 May 28. PMID: 40435348.
Summary: This retrospective cohort study of 922 thoracotomy patients, including 402 undergoing damage control thoracotomy primarily for penetrating trauma, found increasing utilization and improved ICU-free days but no change in mortality, suggesting that while the technique is becoming more common, further research is needed to improve outcomes and closure type should be determined by institutional resources.
