LR vs NS for Pediatric DKA

LR vs NS for Pediatric DKA

Use of any LR in pediatric patients with DKA, as opposed to only NS, was associated with lower overall costs, similar length of stay, and markedly reduced incidence of cerebral edema in this retrospective study.

Hydrocortisone + Fludrocortisone in Septic Shock - APROCCHSS Trial

Hydrocortisone + Fludrocortisone in Septic Shock - APROCCHSS Trial

In patients with septic shock, those treated with hydrocortisone + fludrocortisone had a lower 90-day mortality compared to placebo (43% vs 49.1%, NNT 17). They also had significantly more vasopressor-free and organ-failure free days, in addition to having a shorter time to weaning from vasopressors and mechanical ventilation.

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