Hydrocortisone + Fludrocortisone in Septic Shock - APROCCHSS Trial

Hydrocortisone + Fludrocortisone in Septic Shock - APROCCHSS Trial

In patients with septic shock, those treated with hydrocortisone + fludrocortisone had a lower 90-day mortality compared to placebo (43% vs 49.1%, NNT 17). They also had significantly more vasopressor-free and organ-failure free days, in addition to having a shorter time to weaning from vasopressors and mechanical ventilation.

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