Coagulopathy From Contaminated Synthetic Cannabinoids

Coagulopathy From Contaminated Synthetic Cannabinoids

Think of synthetic cannabinoid use in patients with unexplained serious coagulopathy due to possible contamination with long acting vitamin K antagonists. They will need prolonged oral vitamin K treatment, which can challenging due to the cost.

DOAC vs Warfarin Related Non-Traumatic ICH

DOAC vs Warfarin Related Non-Traumatic ICH

Compared with vitamin K antagonist (VKA)-related non-traumatic intracerebral hemorrhage (ICH), direct oral anticoagulant (DOAC)-related ICH had less disability, smaller bleeds, and the meta-analysis showed lower in-hospital mortality rates.

Does Peds Damage Control Transfusion Help?

Does Peds Damage Control Transfusion Help?

A high plasma to PRBC transfusion ratio (>/= 1:2) was not beneficial in pediatric massive trauma transfusion. But this study was different than adult studies of damage control resuscitation in that these children did not receive platelets

Idarucizumab Works - At Least in the Lab

Idarucizumab Works - At Least in the Lab

Idarucizumab reverses anticoagulation 100% due to dabigatran in the test tube. It seemed to stop active bleeding in patients in about 2.5 hours, and reported operative hemostasis was good.  But since this was an open label trial with no control group, we don't know how the outcomes would have compared with patients who were treated with other procoagulants or who were not treated.

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