What Is a Normal Platelet Count In Pregnancy?

What Is a Normal Platelet Count In Pregnancy?

There is a normal drop in platelet count during pregnancy.  In the first trimester, the normal count is around 250,000 and decreases to about 225,000 at delivery.  Platelet counts <100,000 were rarely encountered in normal, uncomplicated pregnancies and should not generally be considered a physiologic change.

PAMPer - Prehospital Plasma for Hemorrhagic Shock Saves Lives

PAMPer - Prehospital Plasma for Hemorrhagic Shock Saves Lives

Prehospital administration of 2 units of thawed plasma in adult trauma patients at risk for hemorrhagic shock reduced mortality compared to standard care, NNT = 10.

Stop Anticoagulants for Nuisance Bleeding?

Stop Anticoagulants for Nuisance Bleeding?

Nuisance bleeding in patients with atrial fibrillation on oral anticoagulants did not portend subsequent major bleeding or increased risk for stroke/systemic embolism.

Coagulopathy From Contaminated Synthetic Cannabinoids

Coagulopathy From Contaminated Synthetic Cannabinoids

Think of synthetic cannabinoid use in patients with unexplained serious coagulopathy due to possible contamination with long acting vitamin K antagonists. They will need prolonged oral vitamin K treatment, which can challenging due to the cost.

DOAC vs Warfarin Related Non-Traumatic ICH

DOAC vs Warfarin Related Non-Traumatic ICH

Compared with vitamin K antagonist (VKA)-related non-traumatic intracerebral hemorrhage (ICH), direct oral anticoagulant (DOAC)-related ICH had less disability, smaller bleeds, and the meta-analysis showed lower in-hospital mortality rates.

Does Peds Damage Control Transfusion Help?

Does Peds Damage Control Transfusion Help?

A high plasma to PRBC transfusion ratio (>/= 1:2) was not beneficial in pediatric massive trauma transfusion. But this study was different than adult studies of damage control resuscitation in that these children did not receive platelets

Idarucizumab Works - At Least in the Lab

Idarucizumab Works - At Least in the Lab

Idarucizumab reverses anticoagulation 100% due to dabigatran in the test tube. It seemed to stop active bleeding in patients in about 2.5 hours, and reported operative hemostasis was good.  But since this was an open label trial with no control group, we don't know how the outcomes would have compared with patients who were treated with other procoagulants or who were not treated.

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