Outpatient Antibiotic for Pyelonephritis - Ciprofloxacin, TMP/SMX, or Cephalosporins?

Outpatient Antibiotic for Pyelonephritis - Ciprofloxacin, TMP/SMX, or Cephalosporins?

Outpatient treatment failure for pyelonephritis occurred more often in patients treated with fluoroquinolones or trimethoprim-sulfamethoxazole (TMP-SMX) than in patient treated with cephalosporins.

RICO? Rest, Ice, Compression, Opiate for Ankle Sprain?

RICO? Rest, Ice, Compression, Opiate for Ankle Sprain?

Although opioids are not first-line treatment for ankle sprains, an opioid was prescribed for 25% of emergency department patients diagnosed with an isolated ankle sprain. Prescribing varied widely among states. Additionally, patients prescribe greater quantities of opioids were more likely to transition to continued use.

Antibiotic Harms - 70,000 PED Visits a Year

Antibiotic Harms - 70,000 PED Visits a Year

Adverse drug events related to antibiotics led to nearly 70,000 ED visits a year in children ≤19 years.  One out of every 330 children ≤2 years given amoxicillin will end up in the ED with an ADE.

New Risk After TBI - Suicide

New Risk After TBI - Suicide

The incidence of suicide nearly doubled in patients who had traumatic brain injury (TBI) compared to baseline.  Risk increased with severity of injury, number of visits, and was highest in the first 6 months post-injury.

Antibiotic Resistance - The Problem and Solution

Antibiotic Resistance - The Problem and Solution

Most doctors and clinicians think someone else is the problem when it comes to antibiotic resistance and stewardship.  We are the problem.  And we are the solution.

Who's Giving Inappropriate Antibiotics - Urgent Care, Retail, Emergency, or Medical Office?

Who's Giving Inappropriate Antibiotics - Urgent Care, Retail, Emergency, or Medical Office?

Urgent care centers wrote the most inappropriate antibiotic prescriptions for viral respiratory illnesses.  They were followed by the ED, medical offices, and finally by retail health clinics.

Acetaminophen 3rd Trimester and Ductal Closure

Acetaminophen 3rd Trimester and Ductal Closure

Acetaminophen use during late pregnancy was associated with premature ductus arteriosus closure in these two cases.

Can We Use Beta-Blockers With COPD?

Can We Use Beta-Blockers With COPD?

Patients with cardiovascular disease and concomitant COPD can be safely treated with a combination long-acting beta-agonist and a long-acting muscarinic antagonist when on a baseline beta-blocker.

Better Medical Miscarriage Treatment

Better Medical Miscarriage Treatment

In women with confirmed first trimester pregnancy loss, the combination of mifepristone 200mg orally and misoprostol 800μg vaginally at 24 hours vs misoprostol 800μg alone resulted in improved complete expulsion at day 8 (NNT = 6) and decreased need for surgery: 9% vs 24%.

Predicting Outpatient Failure for Cellulitis

Predicting Outpatient Failure for Cellulitis

Tachypnea, chronic ulcers, prior MRSA colonization, and prior cellulitis in the past 12 months were all associated with an increased risk of oral antibiotic failure for treatment of non-purulent cellulitis.

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