EcLiPSE - Should Levetiracetam Replace Phenytoin for Pediatric Status Epilepticus?

EcLiPSE - Should Levetiracetam Replace Phenytoin for Pediatric Status Epilepticus?

There was no difference in levetiracetam vs phenytoin as second-line agents after benzodiazepines for pediatric status epilepticus in median time to seizure cessation. Levetiracetam may have other advantages, as it is able to be given over 5 minutes (vs 20 minutes for phenytoin) and causes fewer adverse effects.

Door-to-Antibiotic And Mortality in Sepsis

Door-to-Antibiotic And Mortality in Sepsis

Mortality was higher when door-to-antibiotic time was > 3 h. However, there was no difference when comparing mortality in those given antibiotics within the first hour to those after the first hour.

Tramadol Isn't Addictive, Right?

Tramadol Isn't Addictive, Right?

Use of tramadol post-op was associated with an increased risk of prolonged use compared with other short acting opiates.

Lemierre's Syndrome - Sore Throat Gone Wrong

Lemierre's Syndrome - Sore Throat Gone Wrong

Sometimes sore throat isn’t just sore throat - it could be a life threatening complication. Learn about Lemierre’s syndrome with this quick-hitter teaching case from NEJM.

Off-Label Gabapentin and Pregabalin - Sketchy Evidence

Off-Label Gabapentin and Pregabalin - Sketchy Evidence

Gabapentinoids play a limited role for specific types of neuropathic pain, and pain reduction is modest at best. Side effects of dizziness, somnolence, and gait problems occur frequently.

New IDSA Guideline on Asymptomatic Bacteriuria

New IDSA Guideline on Asymptomatic Bacteriuria

The IDSA now only recommends screening for and treating asymptomatic bacteriuria (ASB) in pregnant women and those undergoing an invasive urologic procedure.

Do Muscle Relaxers Help Back Pain?

Do Muscle Relaxers Help Back Pain?

There was no benefit in functional outcome or pain at one week by using ibuprofen + either baclofen, metaxolone, or tizanidine over ibuprofen + placebo.

Understanding Lactate in Sepsis - Implications for Early Management

Understanding Lactate in Sepsis - Implications for Early Management

Hyperlactatemia appears to arise from impaired oxygen utilization more often than decreased O2 delivery but doesn’t cause acidemia unless there is impaired renal function. The novel “alactic base excess” may give us an early way to tell when the kidneys are failing to compensate.

ANDROMEDA-SHOCK - Capillary Refill vs. Lactate

ANDROMEDA-SHOCK - Capillary Refill vs. Lactate

Peripheral perfusion guided resuscitation was better than lactate clearance in patients with septic shock in regard to improving organ dysfunction at 72 hours (SOFA score) and barely missed statistical significance in reducing 28-day mortality.

Member Login
Welcome, (First Name)!

Forgot? Show
Log In
Enter Member Area
My Profile Sign up to get full access. Log Out