Corticosteroids did not reduce the incidence of post-herpetic neuralgia at 6 months or pain severity at 3, 6, or 12 months. However, the evidence for this review was fairly weak. Two trials indicated that steroids may reduce short-term pain and speed healing at one month.

Acyclovir within 72-hours of onset of herpes zoster did not reduce pain from post-herpetic neuralgia better than placebo at 4 to 6-month follow up. But it likely helps with acute pain from zoster at 1-month.

In this systematic review and meta-analysis, no single aspect of the physical examination, imaging, or LRINEC score had high enough sensitivity to exclude necrotizing soft tissue infections. Contrast CT performed the best, but it was only 94.3% sensitive at best. If you have a high clinical suspicion, early surgical consultation is necessary for definitive diagnosis and management.

Suturing of facial lacerations by novice physicians resulted in less cosmetically favorable repair in follow up than experienced physicians.

Oral fluconazole is safe to use in pregnancy.

Tachypnea, chronic ulcers, prior MRSA colonization, and prior cellulitis in the past 12 months were all associated with an increased risk of oral antibiotic failure for treatment of non-purulent cellulitis.

Blood cultures were low yield in patients admitted with cellulitis, and should largely be avoided.  Similarly, imaging was also low yield but changed management in a minority of cases.

Sonographically occult perineal abscess in children was surprisingly common, 28% (61/217).  More than half had I&D within 4 hours of a "negative" radiology-obtained ultrasound.  Symptoms < 4 days, age < 4 years, and history of MRSA were all associated with false negative ultrasound.

We can't draw firm conclusions from this paper, since it was not designed or powered to detect differences in subgroups with skin abscesses.  But it was notable that patients who received TMP/SMX did better than those who received placebo across all subgroups, including those with larger abscesses; especially those with fever, history of MRSA, or MRSA positive culture.

Even small abscesses, <5cm, benefitted from antibiotics.  This is contrary to some prior studies' findings that I&D alone was adequate for small abscesses.