If there is any delay in obtaining IV access, give benzodiazepines by a non-IV route to control seizure activity faster.

The window for tPA got wider with this study; ECASS III expanded the time of administration to 4.5 hours.

Think about cervical artery dissection in patients over 60 even if they lack some of the usual features, such as neck pain, mechanical trigger, or migraine.

A mobile stroke treatment unit in Cleveland, equipped with onboard CT scanner and telemedicine, reduced the time to tPA treatment drastically.

HINTS is a 3-part exam that is a powerful bedside discriminator of vertigo caused by a peripheral insult vs. posterior stroke that outperformed MRI.

Use of tPA within 3 hours for acute ischemic stroke improved functional outcome at 3 months but increased early risk for intracranial hemorrhage.

Corticosteroids are definitely beneficial in Bell palsy.  Antiviral agents are not helpful if used alone but have a mild synergistic effect when added to steroids.

Early treatment of anti-NMDA receptor encephalitis improved recovery.  But first, you have to make the diagnosis.

Topiramate and amitriptyline were both ineffective for pediatric migraine prophylaxis and may have caused harm.

Thrombolysis in stroke improves functional outcome but comes at the cost of increased intracranial hemorrhage and early mortality per this big meta-analysis.