Top Health Prevention Articles for Clinicians

Emergency Medicine Infectious Disease Preventive Health Social Drivers of Health

DETECT Hep C RCT – Screening in the Emergency Department
August 26, 2025September 6, 2025

Spoon Feed —
Non-targeted hepatitis C screening in the ED (free regardless of risk) identified more new hepatitis C diagnoses than targeted screening; however, while this found more new cases, it did not translate to increases in successful treatment.

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Hepatitis C Screening in Emergency Departments: The DETECT Hep C Randomized Clinical Trial. JAMA. 2025 Jul 9:e2510563. doi: 10.1001/jama.2025.10563. Epub ahead of print. PMID: 40632510

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ENT/Face Pediatrics Preventive Health

How to Help Deaf or Hard of Hearing Toddlers
August 7, 2025August 4, 2025

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Early Communication Intervention for Deaf/Hard of Hearing Toddlers: A Randomized Clinical Trial. Pediatrics. 2025 Jun 1;155(6):e2024066847. doi: 10.1542/peds.2024-066847. PMID: 40419285

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Pediatrics Preventive Health

Can We Give HPV Vaccine at Age 9-10 Years?
July 25, 2025July 21, 2025

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Clinicians reported that acceptability and feasibility of starting HPV vaccination at age 9 was not significantly lower than starting the series at age 11.

Source
Feasibility and Acceptability of Recommending HPV Vaccine at Ages 9-10 Years. Pediatrics. 2025 Jul 1;156(1):e2024069625. doi: 10.1542/peds.2024-069625. PMID: 40451241

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Family Medicine Internal Medicine Preventive Health Psychiatry | Substance Use Pulmonary/Allergy

Cytisinicline for Smoking Cessation
July 25, 2025July 21, 2025

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Cytisinicline, given for 6 or 12 weeks with behavioral support, significantly increased smoking cessation rates and reduced nicotine cravings compared to placebo.

Source
Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. doi: 10.1001/jamainternmed.2025.0628. PMID: 40257755

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Family Medicine Internal Medicine Preventive Health

Ultraprocessed Food and Mortality Risk
July 8, 2025July 3, 2025

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Higher consumption of ultraprocessed foods is associated with increased all-cause mortality.

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Premature Mortality Attributable to Ultraprocessed Food Consumption in 8 Countries. Am J Prev Med. 2025 Jun;68(6):1091-1099. doi: 10.1016/j.amepre.2025.02.018. Epub 2025 Apr 28. PMID: 40293384

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Family Medicine OB/GYN Pediatrics Preventive Health

Does RSV Vaccination in Pregnancy Make a Difference?
July 3, 2025June 30, 2025

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Vaccination against RSV for pregnant women is effective at decreasing RSV admission and incidence of severe disease for infants less than 6 months.

Source
Real-world effectiveness of RSVpreF vaccination during pregnancy against RSV-associated lower respiratory tract disease leading to hospitalisation in infants during the 2024 RSV season in Argentina (BERNI study): a multicentre, retrospective, test-negative, case-control study. Lancet Infect Dis. 2025 May 5:S1473-3099(25)00156-2. doi: 10.1016/S1473-3099(25)00156-2. Epub ahead of print. PMID: 40339585

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Family Medicine Pediatric Emergency Pediatrics Pharmacy/Pharmacology Preventive Health

Who Benefits from RSV Vaccination?
July 2, 2025June 30, 2025

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Widespread availability of RSV vaccination in the 2024-2025 respiratory season decreased hospitalization rates due to RSV infection, especially for those 0-2 months of age.

Source
Interim Evaluation of Respiratory Syncytial Virus Hospitalization Rates Among Infants and Young Children After Introduction of Respiratory Syncytial Virus Prevention Products – United States, October 2024-February 2025. MMWR Morb Mortal Wkly Rep. 2025 May 8;74(16):273-281. doi: 10.15585/mmwr.mm7416a1. PMID: 40338822

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Endocrine Family Medicine Internal Medicine Pharmacy/Pharmacology Preventive Health

Tirzepatide vs. Semaglutide for Treatment of Obesity
June 27, 2025June 20, 2025

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For the treatment of obesity in non-diabetic adults, tirzepatide was superior to semaglutide in both body weight reduction (20.2% tirzepatide vs 13.7% semaglutide) and waist circumference.

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Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025 May 11. doi: 10.1056/NEJMoa2416394. Epub ahead of print. PMID: 40353578

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Family Medicine GI Internal Medicine Preventive Health

Stool DNA vs. Fecal Immunochemical Tests for Colon Cancer
June 18, 2025June 19, 2025

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Multitarget stool DNA (mt-sDNA) tests detect more colorectal cancer (CRC) than standard fecal immunochemical (FIT) tests.

Source
Multi-target stool DNA and the Fecal Immunochemical Test: A Systematic Review and Meta-analysis on Test Performances. Am J Prev Med. 2025 May 14:107654. doi: 10.1016/j.amepre.2025.107654. Epub ahead of print. PMID: 40379061

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Endocrine Family Medicine Internal Medicine Preventive Health

Zoledronate Q5 Years for Fracture Prevention in Women
June 5, 2025June 5, 2025

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Even with infrequent administration, zoledronic acid effectively prevented morphometric vertebral fracture in early postmenopausal women.

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Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age. N Engl J Med. 2025 Jan 16;392(3):239-248. doi: 10.1056/NEJMoa2407031. PMID: 39813642

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