Using a diagnostic algorithm of revised Geneva, D-dimer, leg ultrasound, CTPA (and V/Q if inconclusive) safely ruled out PE in pregnant women.
There is a normal drop in platelet count during pregnancy. In the first trimester, the normal count is around 250,000 and decreases to about 225,000 at delivery. Platelet counts <100,000 were rarely encountered in normal, uncomplicated pregnancies and should not generally be considered a physiologic change.
Idarucizumab reverses anticoagulation 100% due to dabigatran in the test tube. It seemed to stop active bleeding in patients in about 2.5 hours, and reported operative hemostasis was good. But since this was an open label trial with no control group, we don't know how the outcomes would have compared with patients who were treated with other procoagulants or who were not treated.