Does Prednisone Help Post-herpetic Neuralgia?

Does Prednisone Help Post-herpetic Neuralgia?

Corticosteroids did not reduce the incidence of post-herpetic neuralgia at 6 months or pain severity at 3, 6, or 12 months. However, the evidence for this review was fairly weak. Two trials indicated that steroids may reduce short-term pain and speed healing at one month.

Does Acyclovir Help Post-herpetic Neuralgia?

Does Acyclovir Help Post-herpetic Neuralgia?

Acyclovir within 72-hours of onset of herpes zoster did not reduce pain from post-herpetic neuralgia better than placebo at 4 to 6-month follow up. But it likely helps with acute pain from zoster at 1-month.

Do Antiemetics Work? Droperidol, Ondansetron, Placebo

Do Antiemetics Work? Droperidol, Ondansetron, Placebo

Neither droperidol 1.25mg IV nor ondansetron 8mg IV was better than placebo in achieving an 8mm reduction in nausea on visual analog scale (VAS). But ondansetron was slightly better than droperidol and placebo for overall mean nausea reduction and in patients experiencing the desired effect.

Drip Lidocaine On Skin Before Injection to Reduce Pain

Drip Lidocaine On Skin Before Injection to Reduce Pain

When performing common bedside procedures, drip 1-2 mL of the lidocaine that you are getting ready to inject onto the skin prior to injection. This study suggests that it decreases the patient’s report of pain associated with the procedure.

Do Probiotics Plus Antibiotics Prevent C. difficile?

Do Probiotics Plus Antibiotics Prevent C. difficile?

Probiotics decrease the risk of C. difficile infection in adults and children taking antibiotics and may reduce overall adverse events like cramping, nausea, or diarrhea.

Steroids in Sepsis - ADRENAL and APROCCHSS Included in New Review

Steroids in Sepsis - ADRENAL and APROCCHSS Included in New Review

This rapid review by BMJ included ADRENAL and APROCCHSS along with 40 other RCTs and made a weak recommendation to use corticosteroids (CCS) for patients with sepsis. You’ll want to pull up the free full text with some great infographics.

Inhaled Tranexamic Acid for Hemoptysis?

Inhaled Tranexamic Acid for Hemoptysis?

For patients with hemoptysis, inhaled tranexamic acid was associated with significantly reduced expectorated blood volume, hospital length of stay, need for invasive interventions, and hemoptysis recurrence rate at one year.

Do We Write Antibiotic Rx Because It's Just Easier?

Do We Write Antibiotic Rx Because It's Just Easier?

It took an extra 67 seconds when not prescribing an antibiotic to patients with acute respiratory infection compared to visits in which an antibiotic was prescribed.

Dealing With the ESBL Threat - Extended Spectrum β-lactamase Enterobacteriaceae

Dealing With the ESBL Threat - Extended Spectrum β-lactamase Enterobacteriaceae

Highly resistant, extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae in the urine are becoming increasingly common in unexpected patients in the ED.

Vancomycin/Piperacillin-Tazobactam and AKI

Vancomycin/Piperacillin-Tazobactam and AKI

The combination of vancomycin plus piperacillin-tazobactam (VPT) was associated with increased risk of acute kidney injury (AKI) compared to either drug as monotherapy or other vancomycin - β-lactam combinations, NNH = 11.

Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage

Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage

The table below summarizes the recommendations for adult patients on anti-thrombotic agents with intracranial hemorrhage (both spontaneous and traumatic). This will be focused on ED management.

Do Antiarrhythmic Drugs Help In Cardiac Arrest?

Do Antiarrhythmic Drugs Help In Cardiac Arrest?

When considering 14 RCTs on use of antiarrhythmic drugs for shockable cardiac arrest, there was no benefit for survival to discharge or survival with good neurological outcome. Lidocaine improved ROSC vs placebo.

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