Fluoroquinolone antibiotics were associated with idiopathic intracranial hypertension.
The "upgoing thumb sign" can be used as part of a comprehensive neurological evaluation to help distinguish stroke mimic from actual stroke. It won't replace MRI, but it can be part of the neurological exam, just like we use the Babinski sign. One editorial from 1993 suggested calling it the Hachinski-Babinski, after the discover. Here's how to do it.