Treating skin and soft tissue abscesses with antibiotics in addition to incision and drainage (I&D) resulted in significantly increased clinical cure rate (NNT = 14) and decreased incidence of new lesions (NNT = 10) compared to I&D alone.
A large observational series with over 4,000 intubations compared succinylcholine vs. rocuronium in rapid sequence intubation and found no association between these two paralytics and first-pass intubation success or peri-intubation adverse effects.
High-flow nasal cannula (HFNC) compared to bag-valve mask (BVM) ventilation for preoxygenation of critically ill patients did not improve lowest SpO2 but significantly reduced severe complications (SpO2 < 80%, severe hypotension, and cardiac arrest); 6% HFNC vs. 16% BVM, NNT = 10.
Methylprednisolone acetate 160mg IM was not better than dexamethasone 10mg IM (both given with metoclopramide 10mg IM) for reducing headache days in the week following the ED visit in migraine patients.
Low dose ketamine did not reduce overall pain or opioid use in this study of patients with rib fractures. However, for severely injured patients with ISS>15, ketamine allowed patients to achieve the same level of pain control with significantly less opioid medication.
Corticosteroids did not reduce the incidence of post-herpetic neuralgia at 6 months or pain severity at 3, 6, or 12 months. However, the evidence for this review was fairly weak. Two trials indicated that steroids may reduce short-term pain and speed healing at one month.
Acyclovir within 72-hours of onset of herpes zoster did not reduce pain from post-herpetic neuralgia better than placebo at 4 to 6-month follow up. But it likely helps with acute pain from zoster at 1-month.
When performing common bedside procedures, drip 1-2 mL of the lidocaine that you are getting ready to inject onto the skin prior to injection. This study suggests that it decreases the patient’s report of pain associated with the procedure.