Why We Use Targeted Temperature Not Hypothermia

On the Shoulders of Giants

Clay Smith, MD,  Twitter

Do not refrigerate
This was a multicenter, international RCT with 950 unconscious post-arrest patients who had targeted temperature management to a goal of 33°C or 36°C.  There was no statistical difference between the groups in neurological outcome or survival.  This trial helped clarify that what mattered most in regard to post-arrest temperature management was avoidance of hyperthermia.  Since 36°C is closer to physiologic and there is no advantage to a lower temperature, this has become the preferred target temperature goal.

Spoon Feed
Targeted temperature management, with a goal of 36°C in unconscious post-arrest patients, appeared to be as effective as the more aggressive target of 33°C.

Source/Another Spoonful
Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med. 2013 Dec 5;369(23):2197-206. doi: 10.1056/NEJMoa1310519. Epub 2013 Nov 17.

Peer Reviewed by:
Thomas Davis, MD,  Twitter

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