Blog
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Apr 26 2024
Continued Controversy Between Contrast and Kidneys
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In patients with ACS and concern for STEMI/NSTEMI requiring urgent intervention, randomization to the contrast volume reduction (CVR) group reduced the rate of acute kidney injury (AKI) and sustained kidney damage.Source
Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes. J Am Coll Cardiol. 2024;83(11):1059-1069. doi:10.1016/j.jacc.2024.01.016 -
Apr 25 2024
A Primer on Bayesian Analysis for Non-Statisticians
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Bayesian analysis is becoming more common in clinical research and offers advantages over traditional frequentist methods when used appropriately. This primer can help understand Bayesian analysis better.Source
Introduction to Bayesian Analyses for Clinical Research. Anesth Analg. 2024;138(3):530-541. doi:10.1213/ANE.0000000000006696 -
Apr 24 2024
The Endovascular Therapy Train Continues Onward
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This was an exploratory analysis of the recently published SELECT2 trial, which randomized 352 adults with acute ischemic stroke due to carotid or M1 MCA occlusion to endovascular thrombectomy (EVT) or medical management. The current analysis showed that EVT was superior in functional outcomes across a variety of ischemic severities and penumbra profiles on imaging.Source
Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles. JAMA. 2024;331(9):750-763. -
Apr 23 2024
Time-Dependent Benefit of IV Thrombolysis Before Thrombectomy
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In patients with anterior circulation large-vessel occlusion (LVO) stroke presenting to thrombectomy capable stroke centers, the benefit of intravascular thrombolysis in the setting of endovascular thrombectomy appears to be time-dependent.Source
Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis. JAMA. 2024 Mar 5;331(9):764-777. doi: 10.1001/jama.2024.0589. PMID: 38324409; PMCID: PMC10851137. -
Apr 22 2024
Pulse Oximetry’s Color Bias
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In a controlled hypoxemia study, pulse oximetry was falsely elevated in subjects with darker skin pigmentation and low perfusion.Source
Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin: A Prospective Study. Anesth Analg. 2024 Mar 1;138(3):552-561. doi: 10.1213/ANE.0000000000006755. Epub 2023 Dec 18. PMID: 38109495. -
Apr 19 2024
How Much Epinephrine Is Too Much in ECPR?
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High-dose epinephrine (>3mg) was associated with unfavorable neurologic outcome when compared to low-dose epinephrine (≤3mg) after extracorporeal cardiopulmonary resuscitation.Source
Cumulative epinephrine dose during cardiac arrest and neurologic outcome after extracorporeal cardiopulmonary resuscitation. Am J Emerg Med. 2024 Mar 15;80:61-66. doi: 10.1016/j.ajem.2024.03.013. Epub ahead of print. PMID: 38507848. -
Apr 18 2024
Higher ETCO2 and Better Outcomes in Pediatric Arrest
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Targeted ETCO2 ≥20 mm Hg during pediatric resuscitation was associated with higher rate of survival in patients with in-hospital cardiac arrest. -
Apr 17 2024
IO for OHCA – Humeral Head or Tibia?
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In subgroup analysis, there may be more successful ROSC in patients with upper extremity IO access compared to lower extremity access in OHCA, but these results should be adopted with caution.Source
Retrospective Comparison of Upper and Lower Extremity Intraosseous Access During Out-of-Hospital Cardiac Arrest Resuscitation. Prehosp Emerg Care. 2024 Mar 26:1-8. doi: 10.1080/10903127.2024.2321285. Epub ahead of print. PMID: 38416867. -
Apr 16 2024
Pediatric EMS VS Ranges to Predict Life-Saving Intervention
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Kids frequently present with abnormal vital signs but seldom require prehospital life-saving interventions (LSI). Based on the occurrence of LSI, age-group vital sign ranges were adjusted to better identify critically ill kids. Abnormal respiratory status (RR, SpO2) was strongly associated with prehospital LSI. -
Apr 15 2024
EMS Vital Signs as Mortality Predictors
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Low and high extremes of prehospital vital signs were associated with higher rates of hospitalization and in-hospital mortality; however, there was not statistically significant improvement in their model when using age adjusted vital signs.Correlation of vital sign centiles with in-hospital outcomes among adults encountered by emergency medical services. Acad Emerg Med. 2024 Mar;31(3):210-219. doi: 10.1111/acem.14821. Epub 2023 Nov 3. PMID: 37845192.