JournalFeed Blog | High-Yield Medical Research Summaries

Critical Care Emergency Medicine Neurology Pharmacy/Pharmacology Stroke

Slow and Steady – Be Careful with ICH BP Control
January 15, 2026January 11, 2026

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In this retrospective multicenter study, both early, overly rapid systolic blood pressure (SBP) reduction after intracerebral hemorrhage (ICH) and overshooting SBP targets (<120 mmHg) were linked with worse functional outcomes at discharge.

Source
Early Intensive Blood Pressure Reduction After Intracerebral Hemorrhage Is Associated With Worse Functional Outcome: The Risk of Overshooting Blood Pressure Goals. Ann Emerg Med. 2025 Dec 9:S0196-0644(25)01303-4. doi: 10.1016/j.annemergmed.2025.10.009. Epub ahead of print. PMID: 41369631; PMCID: PMC12757810.

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Emergency Medicine Infectious Disease Pediatric Emergency

Febrile Neonates Under 28 Days – Is PECARN Rule Safe?
January 14, 2026January 11, 2026

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In a large international cohort of well-appearing febrile infants ≤28 days old, the updated PECARN rule had high sensitivity and negative predictive value for invasive bacterial infection, with no missed cases of bacterial meningitis, supporting selective avoidance of routine lumbar puncture in low-risk neonates.

Don’t miss Dr. Josh Belfer’s interview with lead author Dr. Burstein and senior author Dr. Kuppermann on his blog HipPEMcrates.com.

Source
Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger. JAMA. 2025 Dec 8:e2521454. doi: 10.1001/jama.2025.21454. Epub ahead of print. PMID: 41359314; PMCID: PMC12687207.

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Emergency Medicine Pediatric Emergency Pulmonary/Allergy

Eosinophil Count Determines Steroids or Not for Asthma?
January 13, 2026January 9, 2026

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In this trial, randomizing adult patients admitted for asthma exacerbation to shorter duration of steroids (3 days or 5 days) based on their peripheral eosinophil counts was non-inferior to the control group (5 days of steroids).
Source
Blood eosinophil-guided systemic corticosteroid duration in adults hospitalised for asthma exacerbation: a randomised, controlled, open-label, non-inferiority trial. Thorax. 2025 Dec 3:thorax-2025-223961. doi: 10.1136/thorax-2025-223961. Epub ahead of print. PMID: 41339088.

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Orthopedics Pain/Sedation/Procedure POCUS

Reducing Delirium with Fascia Iliaca US-Guided Block
January 12, 2026January 9, 2026

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In this multicenter randomized trial of elderly patients with hip fractures, there was a significant reduction in delirium in those patients who received ultrasound-guided fascia iliaca blocks.

Source
Ultrasound-Guided Regional Anesthesia by Emergency Physicians for Hip Fractures and Delirium: A Randomized Clinical Trial. JAMA Netw Open. 2025 Dec 1;8(12):e2549337. doi: 10.1001/jamanetworkopen.2025.49337. PMID: 41396601; PMCID: PMC12706686.

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Airway Critical Care Emergency Medicine Pediatric Emergency Pharmacy/Pharmacology

Hyperkalemia – Can We Use Succinylcholine for RSI?
January 12, 2026January 12, 2026

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This retrospective cohort study found no 24-hour mortality difference when intubating hyperkalemic patients (K > 5.5mmol/L) with succinylcholine versus rocuronium for RSI.

Source
Hyperkalemic emergency department patients intubated with rocuronium or succinylcholine: Retrospective study of clinical outcomes. Am J Emerg Med. 2025 Dec 2;100:154-164. doi: 10.1016/j.ajem.2025.11.030. Epub ahead of print. PMID: 41380422.

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Cardiology Emergency Medicine Venous Thromboembolism

STORM-PE RCT—Thrombectomy for Intermediate-High Risk PE
January 9, 2026January 10, 2026

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This RCT of 100 patients with intermediate-high risk PE showed that mechanical thrombectomy plus anticoagulation was superior to anticoagulation alone in reducing RV/LV ratio and earlier normalization of vitals.

Source
STORM-PE Trial Investigators. Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. Circulation. 2025 Nov 3. doi: 10.1161/CIRCULATIONAHA.125.077232. Epub ahead of print. PMID: 41183181.

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Cardiology Emergency Medicine

HiSTORIC Reprise—High-Sensitivity Troponin Here to Stay
January 8, 2026January 10, 2026

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High-sensitivity cardiac troponin for risk stratification in both low- and intermediate-risk patients reduced length of stay and increased discharges from the ED for patients with suspected acute coronary syndrome. Also, risk of subsequent myocardial infarction or cardiac death at 1 year was lower.

Source
HiSTORIC Trial Investigators. Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis. J Am Coll Cardiol. 2025 Nov 11;86(19):1738-1748. doi: 10.1016/j.jacc.2025.08.059. PMID: 41193094.

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Emergency Medicine Medicine/Geriatrics Neurology Psychiatry | Substance Use

Discharging Delirium Is Dangerous
January 7, 2026January 10, 2026

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Older adults discharged from the ED with delirium had almost 3 times the risk of 30-day mortality compared to those discharged without delirium.

Source
Outcomes of Older Adults With Delirium Discharged From the Emergency Department. Ann Emerg Med. 2025 Nov;86(5):484-495. doi: 10.1016/j.annemergmed.2025.02.003. Epub 2025 Mar 12. PMID: 40072382; PMCID: PMC12353625.

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Emergency Medicine GI

Lower GI Bleed Scores – Which Best Predicts Badness?
January 6, 2026January 10, 2026

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For lower GI bleeds, the Oakland and SALGIB risk stratification scores performed well in predicting adverse events and severe bleeding and in identifying patients safe for discharge, but none of the 5 scoring systems reliably predicted need for intervention.

Source
Predictive value of clinical risk scores for adverse outcomes and safe discharge in acute lower gastrointestinal bleeding. Am J Emerg Med. 2026 Jan;99:370-375. doi: 10.1016/j.ajem.2025.10.051. Epub 2025 Oct 25. PMID: 41175440.

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Critical Care Emergency Medicine Pediatric Emergency Technology

Can AI Predict Pediatric Sepsis Before It Happens?
January 5, 2026January 5, 2026

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Using EHR data from the first 4 hours of ED care, machine learning models accurately predicted which children would develop sepsis within 48 hours—before organ dysfunction was present.

Source
Derivation and Validation of Predictive Models for Early Pediatric Sepsis. JAMA Pediatr. 2025 Dec 1;179(12):1318-1325. doi: 10.1001/jamapediatrics.2025.3892. PMID: 41082207; PMCID: PMC12519407.

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