Venous Thromboembolism

What’s the Risk of DVT or PE at 1, 2, and 3 Months After Hospital Discharge?

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Risk for venous thromboembolism (VTE) was highest during hospitalization, but the risk remained elevated 3-fold at 3 months post-discharge.

Source
Venous Thrombosis Risk during and after Medical and Surgical Hospitalizations: The Medical Inpatient Thrombosis and Hemostasis (MITH) Study. J Thromb Haemost. 2022 Apr 15. doi: 10.1111/jth.15729. Online ahead of print.

PE? Check… But What’s Next? Ideal Follow-up Post-PE

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The European Society of Cardiology (ESC) has generated a position detailing optimal follow-up of patients following acute pulmonary embolism (PE). They advocate for a holistic approach with consideration of both short- and long-term events encountered by patients diagnosed with acute PE.

Source
Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Ather. Eur Heart J. 2022 Jan 25;43(3):183-189. doi: 10.1093/eurheartj/ehab816.

Prevalence and Significance of Incidental Findings on CTPA

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Computed tomography pulmonary angiography (CTPA) yields an alternative diagnosis to pulmonary embolism (PE) in ~40% of patients with a negative PE study. Alternative diagnoses are more likely to occur in patients with increased age and in patients referred from the hospital setting (ICU or inpatient unit).

Source
Prevalence and significance of incidental findings on computed tomography pulmonary angiograms: A retrospective cohort study. Am J Emerg Med. 2022 Apr;54:232-237. doi: 10.1016/j.ajem.2022.01.064.

Importance of RV Assessment in Low-Risk PE

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Among patients with symptomatic PE who are low risk by sPESI, the addition of right ventricular assessment predictors (echo, CT, troponin, and BNP) significantly improved prognostication for clinical deterioration within 5 days. 

Source
Can right ventricular assessments improve triaging of low risk pulmonary embolism? Acad Emerg Med. 2022 Mar 15. doi: 10.1111/acem.14484. Online ahead of print.

HEP-COVID RCT -Full Dose Anticoagulation for COVID-19?

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In adult COVID-19 patients with high thrombosis risk, empiric therapeutic dose enoxaparin reduced a composite outcome incidence of thrombotic events or 30-day all-cause mortality relative to prophylactic regimens with no significant difference in major bleeding. The difference was driven by a reduction in venous thromboembolism (VTE) and was not observed in ICU patients.

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