Mar 11 2022
Heart Rate and Mortality in Acute PE
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Elevated heart rate is associated with increased risk of mortality for patients with acute symptomatic pulmonary embolism. Be wary of patients with acute pulmonary embolism who are tachycardic.
Feb 21 2022
Apixaban or Rivaroxaban – Which Is Best for VTE?
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Apixaban and rivaroxaban are two of the most prescribed direct oral anticoagulants (DOACs), but there are limited head-to-head comparisons of the medications. This study finds apixaban is associated with lower rates of VTE recurrence, GI bleeds and ICH compared to rivaroxaban.
Jan 28 2022
The Ideal PE Rule-Out? RCT – PERC+YEARS+Age-Adjusted D-Dimer
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In PERC positive patients, use of YEARS with age-adjusted D-dimer was noninferior to an age-adjusted D-dimer strategy alone.
Jan 27 2022
HEP-COVID RCT -Full Dose Anticoagulation for COVID-19?
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In adult COVID-19 patients with high thrombosis risk, empiric therapeutic dose enoxaparin reduced a composite outcome incidence of thrombotic events or 30-day all-cause mortality relative to prophylactic regimens with no significant difference in major bleeding. The difference was driven by a reduction in venous thromboembolism (VTE) and was not observed in ICU patients.
Jan 26 2022
Update on Antithrombotic Therapy for VTE Disease
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We dig into the new VTE update on antithrombotic therapy in this post.
Jan 25 2022
Prediction of Early Major Bleeding in Acute PE
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A new risk score (PE-SARD) stratifies patients with acute pulmonary embolism (PE) to predict early, major bleeding events.
Jan 20 2022
New PE-SCORE – Predicting Near-Term PE Outcomes
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The PE-SCORE has been derived and validated to determine which patients with PE are at risk of clinical deterioration or death. Patients with a score of 0 had an 8% chance of deterioration but no death; scores ≥6 all had deterioration or death.
Jan 11 2022
Subsegmental PE – Small But Significant?
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Patients with single and multiple isolated subsegmental pulmonary embolism (SSPE) without proximal deep venous thrombosis (DVT) managed without anticoagulation had an incidence of recurrent venous thromboembolism (VTE) of 3.1% (95% CI, 1.6% to 6.1%) within 90 days. This incidence of recurrent VTE was higher than expected and has implications for management of these patients with anticoagulation.
Nov 15 2021
Does Proactive PE Screening Improve COPD Admission Outcomes?
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In patients hospitalized for a COPD exacerbation, addition of an active strategy for the diagnosis of pulmonary embolism plus usual care compared to usual care alone did not significantly improve the composite outcome of nonfatal new or recurrent venous thromboembolism, readmission for COPD, or death at 90 days.
Nov 12 2021
Pregnancy-Adapted Geneva Score – Pre-test Probability of Acute PE in Pregnancy
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In this prospective cohort, a pregnancy-adapted Geneva Score demonstrated better diagnostic accuracy than the original Geneva Score in identifying pregnant patients as low, intermediate, and high risk for acute pulmonary embolism.