A non-invasive approach to monitoring sepsis patients by using lactate clearance rather than central venous O2 saturation was just as effective once central venous pressure and mean arterial pressure were optimized.

Implicit racial bias is likely influencing us in the ED, but whether that translates into impacting clinical decision making remains to be seen.

Patients intubated in the Emergency Department with usual care (no apneic oxygenation) vs apneic oxygenation (≥15L/min via nasal cannula) did not have significant differences in lowest mean oxygen saturation.

Even though early goal-directed therapy has subsequently been shown to be no more effective than usual care, this landmark trial put a spotlight on sepsis care, especially starting aggressive measures as early as possible in the ED.

Meningitis was a very rare cause of status epilepticus (SE) in this retrospective single-center review.

Supine position to improve cerebral blood flow in ischemic stroke patients did not impact outcome positively or negatively compared to head-of-bed elevation 30 degrees.

Non-invasive ventilation (NIV) in patients with acute exacerbation of COPD decreased the need for intubation and reduced in-hospital mortality.

This early study of thrombolytics plus heparin for submassive PE showed no mortality benefit but did show a decrease in need for escalation of care compared with heparin alone.  Subsequent studies call lytics for submassive PE into question, so take the current evidence into account.

Excessive sedation of intubated adult patients in the ED was associated with increased in-hospital mortality.  Aim for a RASS > -3.

Low tidal volume ventilation reduced mortality in patients with acute lung injury.  If you want to learn more, see this post on Managing the Vent Like a Pro.