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Clinically relevant bleeding events were more common after central venous catheter placement in patients with platelet counts of 10,000 to 50,000/mm3 who did not receive prophylactic platelet transfusion than those who did.
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Pregnant patients who present with signs and symptoms concerning for PE can be safely evaluated using Wells criteria or the YEARS algorithm.
Source
Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data. J Thromb Haemost. 2023 Mar;21(3):606-615. doi: 10.1016/j.jtha.2022.11.025. Epub 2022 Dec 22.
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This well-designed RCT finds early administration of 4-factor prothrombin complex concentrate (PCC) to patients at risk of receiving massive transfusion protocol (MTP) did not reduce 24-hour blood product consumption or mortality but did increase thrombotic events.
Source
Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial. JAMA. 2023 Mar 21. doi: 10.1001/jama.2023.4080. Online ahead of print.
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Not all pediatric bruising needs workup for a bleeding disorder. This report details not only how but when to do it.
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Cancer-associated hypercalcemia requires prompt recognition and treatment in the ED, starting with aggressive rehydration +/- loop diuretics as well as coordination of initiation of bone resorption inhibition, which can take up to 48 or longer hours to have a full effect.
Source
Cancer-Associated Hypercalemia. N Engl J Med 2022; 386: 1443-51. DOI 10.1056/NEJMcp2113128.
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Delayed intracranial hemorrhage for patients on direct oral anticoagulant therapy with minor traumatic brain injury is rare (~1.5%) after a negative initial head CT.
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In patients that develop febrile neutropenia, procalcitonin levels were better at identifying those at a higher risk for 30-day mortality and bacteremia than the commonly used MASCC score.
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Postpartum hemorrhage is defined as ≥1000mL of blood loss irrespective of the delivery route, with associated shock. Remember the four “T’s”: tone (uterine atony), trauma (lacerations, uterine rupture), tissue (retained placenta, clots) and thrombin (coagulopathies). Manage the ABCs (especially two large bore IV’s for massive transfusion) and tailor treatment to the specific cause. Recommendations for balanced transfusion are derived from the trauma literature, but it is important to administer cryoprecipitate earlier to maintain a higher fibrinogen level (at term the normal level is >350mg/dL).
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There is a very low, perhaps 0% bleeding and mortality risk, in performing thoracentesis or tube thoracostomy on patients taking antiplatelet or anticoagulant agents or those with thrombocytopenia or coagulopathy from a disease process, like cirrhosis.
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CT abdomen and pelvis is associated with a higher incidence of hematologic malignancies over a two year span, especially in younger patients.
