tPA 4.5 to 9h or Wake-Up Stroke – New Meta-analysis
Compared to the placebo group, patients who presented with ischemic stroke (4.5-9h from onset or wake-up stroke) with salvageable brain tissue identified on perfusion imaging and received tPA, had a slight improvement in functional outcome (mRS of 0-1) at 3 months (36% vs 29%) with higher rates of symptomatic intracerebral hemorrhage (5% vs <1%).