In the spectrum of heat related illness, heat stroke is a can’t miss diagnosis. Aggressive management, with rapid cooling to 38-39°C within 30 minutes of presentation at a rate of 0.20-0.35°C per minute has been shown to not only be safe but improve outcomes.
Treatment and Prevention of Heat-Related Illness. N Engl J Med. 2022 Oct 13;387(15):1404-1413. doi: 10.1056/NEJMcp2210623. Epub 2022 Sep 28.