High flow nasal cannula did not reduce 28-mortality in immunocompromised patients with acute hypoxemic respiratory failure compared to standard oxygen therapy.

Immune checkpoint inhibitors are monoclonal antibodies that block inhibitors of T-cell activation and function. They are increasingly used in different malignancies by removing inhibition of T-cell function and have an array of toxic side effects you need to know.

Using a diagnostic algorithm of revised Geneva, D-dimer, leg ultrasound, CTPA (and V/Q if inconclusive) safely ruled out PE in pregnant women.

For patients with hemoptysis, inhaled tranexamic acid was associated with significantly reduced expectorated blood volume, hospital length of stay, need for invasive interventions, and hemoptysis recurrence rate at one year.

The table below summarizes the recommendations for adult patients on anti-thrombotic agents with intracranial hemorrhage (both spontaneous and traumatic). This will be focused on ED management.

Administration of plasma first for traumatic hemorrhagic shock when brought by ground did not change 28-day mortality.

Incidence of intracerebral hemorrhage (ICH) on CT following minor head trauma in anticoagulated patients was 9%, which means we have to CT all these people.

There is a normal drop in platelet count during pregnancy.  In the first trimester, the normal count is around 250,000 and decreases to about 225,000 at delivery.  Platelet counts <100,000 were rarely encountered in normal, uncomplicated pregnancies and should not generally be considered a physiologic change.

Prehospital administration of 2 units of thawed plasma in adult trauma patients at risk for hemorrhagic shock reduced mortality compared to standard care, NNT = 10.

Nuisance bleeding in patients with atrial fibrillation on oral anticoagulants did not portend subsequent major bleeding or increased risk for stroke/systemic embolism.