This meta-analysis of 4 RCTs found anti-MRSA antibiotics in addition to I&D led to a far better cure rate than I&D alone.

If you're still reaching for metronidazole in patients with suspected or confirmed C. difficile colitis, it's time to get up to speed with this summary.

Normal CSF looks different in neonates and infants 29-60 days. Here are the reference values.

Opiate use was associated with invasive pneumococcal disease.

Bacteremia and bacterial meningitis occurred in 3.1% and 1.3% of infants </=28 days, respectively; 1.1% and 0.2% of infants 29-60 days, respectively.  With a 1/500 chance of bacterial meningitis in infants 29-60 days, reasonable physicians may disagree on the merits of the lumbar puncture in this group.

HSV was rare in infants under 60 days, <1%.  However, 9% occurred in weeks 5-6 and 11% in weeks 7-9, which was a much later onset than previously thought.

Sensitivity for UA with any leukocyte esterase, nitrite, or >5 WBCs/hpf was 94% for UTI growing >50,000 colony forming units (CFU).

Influenza particles are released simply by breathing.  That means, a person does not have to cough or sneeze to spread the flu - just breathing will do it.  This has infection control implications.

Don't be falsely reassured if rhinovirus on a PCR viral panel is positive.  The incidence of UTI was unchanged if </= 90 days, and the incidence of invasive bacterial infection (IBI) was no different </= 28 days.  However, it may prove useful for risk stratifying infants for IBI in the 29 to 90-day age group.

A push to use cephalexin vs cefixime for uncomplicated pediatric UTI was successful at this medical center.  Whether this is an improvement in prescribing depends upon local E. coli resistance.