Lean Left – IVC Compression in Pregnancy
A 30° left tilt in late pregnancy was most effective in reducing uterine compression of the IVC in this MRI study. However, nearly a quarter of women achieved the greatest IVC volume with a 30° right tilt.
Can We Use Ondansetron In Pregnancy?
In this large cohort study of over 1.8 million pregnancies, first trimester ondansetron use was not associated with cardiac malformations or total congenital malformations. However, there was a small increased risk of oral clefts (3 additional cases per 10,000 women treated).
Is Routine Pelvic Exam Beneficial for STI Detection?
Pelvic examination added little to clinical judgment when evaluating for sexually transmitted infections in young women.
PE Workup in Pregnancy – New Evidence
Using a diagnostic algorithm of revised Geneva, D-dimer, leg ultrasound, CTPA (and V/Q if inconclusive) safely ruled out PE in pregnant women.
Drinking More Water Prevents Cystitis
In premenopausal women with recurrent cystitis, drinking more water on a daily basis can reduce episodes of cystitis.
β-blockers Appear Safe in Pregnant Patients with HTN
β-blockers appear safe to use in hypertensive pregnant patients in the first trimester.
Forget the Blood Patch? A Medical Option That Works
Administration of neostigmine and atropine vs placebo, in addition to usual care for post-dural puncture headache (PDPH), was highly effective in this RCT involving healthy postpartum women.
What Is a Normal Platelet Count In Pregnancy?
There is a normal drop in platelet count during pregnancy. In the first trimester, the normal count is around 250,000 and decreases to about 225,000 at delivery. Platelet counts <100,000 were rarely encountered in normal, uncomplicated pregnancies and should not generally be considered a physiologic change.
Acetaminophen 3rd Trimester and Ductal Closure
Acetaminophen use during late pregnancy was associated with premature ductus arteriosus closure in these two cases.
Better Medical Miscarriage Treatment
In women with confirmed first trimester pregnancy loss, the combination of mifepristone 200mg orally and misoprostol 800μg vaginally at 24 hours vs misoprostol 800μg alone resulted in improved complete expulsion at day 8 (NNT = 6) and decreased need for surgery: 9% vs 24%.