June 2022

A Spoonful of Sugar – Does Open-Label Placebo Work?

GI, Pediatrics, Pharmacy/Pharmacology

Spoon Feed
Children with functional abdominal pain and irritable bowel syndrome taking an open-label placebo reported significantly less pain and took fewer rescue pain medications.

Source
Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Apr 1;176(4):349-356. doi: 10.1001/jamapediatrics.2021.5750. Erratum in: doi: 10.1001/jamapediatrics.2022.0359.

Pre-AeRATE RCT – HFNC 60L vs NC 15L for Apneic Oxygenation

Airway, Critical Care

Spoon Feed
There was no benefit to using high-flow nasal cannula at 60L/min vs regular NC at 15L/min for pre- and apneic oxygenation during emergency department intubations.

Source
Pre- and apnoeic high-flow oxygenation for rapid sequence intubation in the emergency department (the Pre-AeRATE trial): A multicentre randomised controlled trial. Ann Acad Med Singap. 2022 Mar;51(3):149-160. doi: 10.47102/annals-acadmedsg.2021407.

Does pSOFA in the PED Predict Mortality?

Critical Care, Pediatrics

Spoon Feed
The pSOFA score was not a good screening tool for predicting in-hospital mortality when used in a pediatric emergency department (PED) setting.

Source
Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Third International Consensus Definitions for Sepsis and Septic Shock Definitions in the Pediatric Emergency Department. JAMA Pediatr. 2022 May 16. doi: 10.1001/jamapediatrics.2022.1301. Online ahead of print.

CASH-75 – Atypical Pneumonia Predictor Score

Infectious Disease, Pharmacy/Pharmacology, Pulmonary/Allergy

Spoon Feed
Using the CASH-75 score can help predict the absence of atypical pathogens (L. pneumophila or M. pneumoniae) as the causative agents of community acquired pneumonia (CAP) in hospitalized patients.

Source
Accuracy of a score predicting the presence of an atypical pathogen in hospitalized patients with moderately severe community-acquired pneumonia. BMC Infect Dis. 2022 May 3;22(1):424. doi: 10.1186/s12879-022-07423-1.

Pediatric Asthma – One or Two-Dose Dexamethasone?

Pediatrics, Pharmacy/Pharmacology, Pulmonary/Allergy

Spoon Feed
A single dose of dexamethasone was as effective as two in treatment of mild to moderate pediatric asthma exacerbations in the emergency department.

Source
Single-Dose Dexamethasone Is Not Inferior to 2 Doses in Mild to Moderate Pediatric Asthma Exacerbations in the Emergency Department. Pediatr Emerg Care. 2022 May 3. doi: 10.1097/PEC.0000000000002727. Online ahead of print.

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