Month: August 2022

Should We Stop Using Propofol for RSI? | The INTUBE Study

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Patients who suffer from peri-intubation cardiovascular instability and collapse have an increased risk of mortality. Propofol was significantly associated with increased risk of peri-intubation instability and collapse.

Source
Peri-intubation Cardiovascular Collapse in Patients Who Are Critically Ill: Insights from the INTUBE Study. Am J Respir Crit Care Med. 2022 Aug 15;206(4):449-458. doi: 10.1164/rccm.202111-2575OC.

The TBI SBP Sweet Spot – Is 130-180 mmHg the New Normotension?

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In-hospital mortality of TBI patients decreased linearly as the lowest observed out-of-hospital systolic blood pressure increased, with the lowest mortality between 130 and 180 mmHg.

Source
Optimal Out-of-Hospital Blood Pressure in Major Traumatic Brain Injury: A Challenge to the Current Understanding of Hypotension. Ann Emerg Med. 2022 Jul;80(1):46-59. doi: 10.1016/j.annemergmed.2022.01.045. Epub 2022 Mar 24.

What ECG Findings Predict Crashing in Acute PE?

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In patients with acute pulmonary embolism, only supraventricular tachycardia was an independent predictor of clinical deterioration; however, other ECG findings (below) were associated with abnormal RV function on echo.

Source
Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism. Acad Emerg Med. 2022 Jun 24. doi: 10.1111/acem.14554. Online ahead of print.

TXA for Epistaxis Just Can’t Make up its Mind

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This single center, double blinded, randomized control trial of 240 patients demonstrated several positive outcomes with addition of tranexamic acid (TXA) to standard therapy.

Source
Intranasal Topical Application of Tranexamic Acid in Atraumatic Anterior Epistaxis: A Double-Blind Randomized Clinical Trial. Ann Emerg Med. 2022 Jun 22;S0196-0644(22)00247-5. doi: 10.1016/j.annemergmed.2022.04.010. Online ahead of print.

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