In patients admitted to the ICU, use of balanced fluids resulted in a lower rate of major acute kidney events (MAKE) at 30 days compared to normal saline (14.3% vs 15.4%). This is a NNT of 94 to avoid one MAKE.

In non-critically ill patients that received IV fluids in the ED, there was a lower incidence of major adverse kidney events in the balanced crystalloid group compared to saline (4.7% vs 5.6%) with a NNT of 111. There was no difference in terms of hospital-free days between the groups.

Fluoroquinolone use was associated with increased risk of developing newly diagnosed aortic aneurysm or dissection.

Acetaminophen (APAP) was not inferior to diclofenac or APAP+diclofenac for acute extremity pain at 90 minutes.

This meta-analysis of 4 RCTs found anti-MRSA antibiotics in addition to I&D led to a far better cure rate than I&D alone.

The J-tip needle-free injection of lidocaine was no better than topical anesthetic (EMLA) in reducing infant LP pain scores, but it improved LP procedural success.

This systematic review suggested that we don't know if treating subsegmental PE harms or helps.  But this may inform decision making in patients in whom it would be very dangerous to anticoagulate.  It suggests a state of equipoise.

In patients with septic shock, those treated with hydrocortisone + fludrocortisone had a lower 90-day mortality compared to placebo (43% vs 49.1%, NNT 17). They also had significantly more vasopressor-free and organ-failure free days, in addition to having a shorter time to weaning from vasopressors and mechanical ventilation.

Emergency clinicians who underestimated their own opiate prescribing were impacted more profoundly to reduce prescriptions by being shown their opiate prescribing data compared to their peers.

If you're still reaching for metronidazole in patients with suspected or confirmed C. difficile colitis, it's time to get up to speed with this summary.